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👉🏼 This August, researchers from the Netherlands (Melissa de Bie et al.) published a systematic review in Critical Care Medicine on Patient-Ventilator Asynchrony (PVA), evaluating its association with relevant clinical outcomes, such as:

• Total duration of mechanical ventilation

• ICU length of stay

• Mortality

👉🏼 19 studies included with 2672 patients.

👉🏼 Key findings from the meta-analysis:

Ineffective efforts and double triggering were associated with:

🥲 Longer duration of mechanical ventilation

• Mean difference: 3.29 days

• 95% CI: 0.13–6.44 days

🥲 Longer ICU length of stay

• Mean difference: 3.65 days

• 95% CI: 1.20–6.11 days

🤔 No association was found between PVA and mortality.

🧐 Interestingly, reverse triggering showed a potential positive association with clinical outcomes.
👉🏼 This intriguing finding opens the door for deeper discussion: how could this specific type of asynchrony potentially have a protective effect?

👉🏼 This adds to the growing body of evidence linking PVA to significant clinical outcomes.
Identifying and managing asynchronies remains a key part of caring for patients on mechanical ventilation.

🔗 Link to the article:

de Bie, Melissa J. MSc1,2; Rietveld, Petra J. BSc2; van der Velde-Quist, Franciska MD2; van Geloven, Nan MSc, PhD3; Snoep, Jacob W. M. BSc2; de Jonge, Evert MD, PhD2; Schoe, Abraham MD, PhD2. The Association Between Patient-Ventilator Asynchrony and Clinical Outcomes in Mechanically Ventilated Patients: A Systematic Review. Critical Care Medicine ():10.1097/CCM.0000000000006816, August 12, 2025.

👉🏼 If you found this interesting, share it!
🧐 And you — how do you manage asynchronies in your daily ventilator management practice?