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📜 Journal Club | High-flow nasal cannula oxygen during breaks from noninvasive ventilation after extubation: an observational study

By: BETINA SANTOS TOMAZ, FISIOTERAPEUTA - 08/03/2026 10:27

🧐 In July 2026, the authors:

  • Arnaud W. Thille (CHU Poitiers, France)
  • Rémi Coudroy (CHU Poitiers, France)
  • Jean-Pierre Frat (CHU Poitiers, France)

and collaborators from a large French multicenter research network,

📜 Published an observational study in Intensive Care Medicine entitled "High-flow nasal cannula oxygen during breaks from noninvasive ventilation after extubation: an observational study." The study investigated whether the use of high-flow nasal cannula (HFNC) during breaks from noninvasive ventilation (NIV) after extubation could reduce extubation failure in high-risk critically ill patients admitted to intensive care units. The analysis included data from 1,077 patients enrolled in two large multicenter clinical trials.

🙂 Using a rigorous methodological approach and robust statistical analysis, including G-computation to adjust for potential confounding factors, the authors found that the strategy of alternating NIV with HFNC was associated with lower unadjusted rates of extubation failure and a reduced need for reintubation within the first 48 hours. However, after adjustment for confounders, these differences were no longer statistically significant, suggesting that the findings should be considered hypothesis-generating. The authors emphasize that adequately powered randomized controlled trials specifically designed to address this question are still needed.
 
📊 Infographic summarizing the main findings of the study.

📖 Full article:

Thille AW, Chamblet L, Ragot S, Gacouin A, Nay MA, Ehrmann S, et al. High-flow nasal cannula oxygen during breaks from noninvasive ventilation after extubation: an observational study. Intensive Care Med. 2026. doi:10.1007/s00134-026-08544-w.


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